Turned on by danger: activation of CD1d-restricted invariant natural killer T cells
نویسندگان
چکیده
منابع مشابه
CD1d-Restricted Natural Killer T Cells
Natural killer T (NKT) cells that express the semi-invariant T-cell receptor are innate-like lymphocytes whose functions are controlled by self and foreign glycolipid ligands. Such ligands are presented by the antigen-presenting, MHC class I-like molecule CD1d, which belongs to a family of lipid antigen-presenting molecules collectively called CD1. Activation of NKT cells in vivo results in rap...
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Invariant natural killer T (NKT) cells are a highly conserved subset of T lymphocytes expressing a semi-invariant T cell receptor (TCR), which is restricted to CD1d and specific for the glycosphingolipid antigen alpha-galactosylceramide. Their ability to secrete a variety of cytokines, which in turn modulate the activation of cells of both innate and acquired immune responses, suggests that inv...
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The immune system plays a major role in protecting the host against viral infection. Rapid initial protection is conveyed by innate immune cells, while adaptive immunity (including T lymphocytes) requires several days to develop, yet provides high specificity and long-lasting memory. Invariant natural killer T (iNKT) cells are an unusual subset of T lymphocytes, expressing a semi-invariant T ce...
متن کاملFunctionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional activities are regulated. Using lipid antigen-loaded CD1d tetramers, we have distinguished two subsets of CD1d-restricted T cells in fresh peripheral blood that differ in cytokine production and cytotoxic activatio...
متن کاملAdaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.
The semi-invariant natural killer (NK) T-cell receptor (NKTcr) recognises structurally diverse glycolipid antigens presented by the monomorphic CD1d molecule. While the alpha-chain of the NKTcr is invariant, the beta-chain is more diverse, but how this diversity enables the NKTcr to recognise diverse antigens, such as an alpha-linked monosaccharide (alpha-galactosylceramide and alpha-galactosyl...
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ژورنال
عنوان ژورنال: Immunology
سال: 2012
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2012.03612.x